Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns.

ABSTRACT:

Background

Congenital heart disease (CHD) lesions are the most common birth defects and despite advances in care, are associated with short- and long-term co-morbidities. The exact mechanisms that may influence outcomes in survivors with CHD remain unclear and are likely multi-factorial; exploring the epigenome in these cases may provide novel insights into predictive biomarkers contributing to outcomes. The present study characterizes the impact of CHD on the newborn epigenome through assessments of epigenetic age.

Methods

This is a prospective, single-site case-control pilot study conducted at Children's National Hospital with subjects enrolled from the Washington DC Metropolitan area. Genomic samples were collected between 2018 and 2024 and analyzed using the Illumina Met

SUBMITTER: Kocher K 

PROVIDER: S-EPMC12305921 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature