Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs.

ABSTRACT:

Background

Burn pits, a method for disposal of military waste outside the United States, produce toxic substances, to which 3.5 million military personnel have been and continue to be exposed. Mild asthma (persistent or intermittent symptoms of asthma but no change in pulmonary function tests) is found among military personnel. We investigated whether burn pit combustion products (CPs) are more detrimental to the airways of asthmatic than non-asthmatic mice.

Methods

Mice were exposed to house dust mite antigen (HDM) or phosphate-buffered saline (PBS) 5 times over 2 weeks to initiate asthma-like airway injury. Condensates of CPs or saline were generated by flaming combustion of military cardboard, plastic and military plywood. CPs were aspirated oropharyngeally at 24 h after

SUBMITTER: Belfield-Simpson L 

PROVIDER: S-EPMC12305933 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature