Global, regional, and national burden and trends of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis in adolescents and adults aged 15-49 years from 2010 to 2021: insights from the global burden of disease study 2021.

ABSTRACT:

Background

Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) among those aged 15-49 years pose a severe public health challenge, yet our understanding of the burden of these diseases in this age group remains limited. This study aimed to evaluate the trends in MDR-TB and XDR-TB burden among this population from 2010 to 2021 across global, regional, and national levels.

Methods

This study extracted four key indicators-incidence, prevalence, deaths, and disability-adjusted life years (DALYs) per 100,000 population-for MDR-TB and XDR-TB among 15-49 years from the 2021 Global Burden of Disease (GBD) study. It assessed the burden trends using percentage change (PC) and estimated annual percentage change (EAPC), with further analysis by

SUBMITTER: Cui K 

PROVIDER: S-EPMC12305936 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature