T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus.

ABSTRACT:

Background

Cytomegalovirus (CMV) infection, with limited therapeutic options, represents a significant complication following transplantation. T cell receptor (TCR)-like antibodies that can recognize and bind to viral peptides presented by the human leukocyte antigen (HLA) show promise for specifically targeting and eliminating CMV-infected cells. Here, we show that this humanized TCR-like antibody efficiently targets CMV-infected cells, thereby supporting the development of this novel and effective therapeutic option for patients.

Methods

Using a synthetically produced pCMV-pp65_{495 - 503}/HLA-A2 as an antigen, we screen for specific antibodies against pCMV-pp65_{495 - 503}/HLA-A2 and design a humanized TCR-like antibody. The affinity of the antibody for th

SUBMITTER: Chen D 

PROVIDER: S-EPMC12306020 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature