Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.

ABSTRACT:

Background

Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the neuroendocrine system plays a central role in HS responses by activating the hypothalamic-pituitary-adrenal and sympathetic-adrenal-medullary axes. This study explores the neural transcriptomic changes and metabolomic profile subjected to HS, aiming to unravel the complexity of nervous adaptive responses, including the disrupted lipid metabolism, impaired immunity, and neural damage processes.

Results

Based on the designed chicken HS model, we identified 1,871 serum metabolites, with 149 differentially accumulated metabolites (DAMs

SUBMITTER: An B 

PROVIDER: S-EPMC12306051 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature