Targeting the complement-mTOR-autophagy axis: the role of apolipoprotein E in depression.

ABSTRACT:

Background

Depression is a highly prevalent and debilitating psychiatric disorder, and while Apolipoprotein E (ApoE), a critical regulator of lipid transport and neuronal function, has been implicated in regulating depressive behaviors, the underlying mechanisms remain insufficiently understood.

Results

In this study, we explored the role of ApoE in depression using complementary animal models. We observed significantly reduced ApoE levels in the hippocampus of both chronic social defeat stress (CSDS) and lipopolysaccharide (LPS)-induced depression models, with ApoE knockout (ApoE^-/-) mice exhibiting exacerbated depressive-like behaviors. Hippocampal ApoE overexpression effectively reversed these behavioral deficits, demonstrating ApoE's essential role in modulati

SUBMITTER: Li Y 

PROVIDER: S-EPMC12306099 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature