Agglutination of yeast-binding antibodies from human blood plasma products.

ABSTRACT:

Background

Yeasts are ubiquitous microorganisms found both endogenously within the human body and in the environment. Humoral responses against yeasts lead to the production of yeast-binding antibodies, which can agglutinate yeast cell targets. These antibodies affect the accuracy of immunodiagnostic tools employing yeast cells as in recombinant surface antigen display.

Aim

To improve the applicability of such tools, the study aims to determine the abundance and characterize the agglutinating behavior of yeast-binding antibodies.

Methodology

The study employed the use of a yeast agglutination assay to determine the prevalence of agglutination across human fresh frozen plasma samples (n = 36). The mean area of the agglutinin complex served as the basis for differentiat

SUBMITTER: Falcon RMG 

PROVIDER: S-EPMC12306107 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature