Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study.

ABSTRACT:

Background

Emerging epidemiological studies have identified associations between perianal abscess (PA) and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), though the pathophysiological mechanisms underlying their comorbidity remain incompletely understood. To elucidate potential causal relationships between these clinical entities, we conducted a comprehensive investigation employing bidirectional two-sample Mendelian randomization (MR) analysis complemented by multivariable Mendelian randomization (MVMR) methodology. This analytical approach enables systematic evaluation of causal directionality while accounting for potential confounding factors inherent in observational studies.

Methods

To establish valid instrumental variables

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12306110 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature