Host-pathogen interaction profiling of nontypeable <i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis</i> coinfection of bronchial epithelial cells.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease and the third leading cause of death globally. Nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are common pathogens in individuals with COPD. Acquisition of NTHi or Mcat can cause acute exacerbations of COPD. NTHi and/or Mcat also persist for months in the lower airways and lead to chronic inflammation. We hypothesized that infection by NTHi or Mcat, singly or during coinfection, requires regulation of specific bacterial and host cell pathways. We investigated this phenomenon using an in vitro cell culture model consisting of lung carcinoma H292 cell lines, infected with NTHi, Mcat, or both species. Samples were fractionated into "apical fluid," containing

SUBMITTER: D'Mello A 

PROVIDER: S-EPMC12306180 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature