Comparative effectiveness of missed dose protocols of opioid agonist treatment in British Columbia, Canada: protocol for a population-based target trial emulation.

ABSTRACT:

Introduction

Methadone and buprenorphine/naloxone are effective medications for people with opioid use disorder; however, interruptions in daily dosing are common and diminish the benefits of these medications. While clinical guidelines in most North American jurisdictions, including British Columbia (BC), recommend dose adjustment after treatment interruptions to varying levels of specificity, the evidence to support these recommendations is limited. We aim to estimate the comparative effectiveness of alternative dose adjustment strategies on subsequent overdose-related acute care visits and discontinuation of opioid agonist treatment in BC, Canada.

Methods and analysis

Using a linkage of nine health administrative databases, we propose a population-level retrospective coho

SUBMITTER: Mondol MH 

PROVIDER: S-EPMC12306210 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature