FAT1-weighted MRI-guided focused ultrasound thalamotomy for essential tremor.

ABSTRACT:

Background and objective

Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy of the ventral intermediate nucleus (Vim) is an effective therapy for medication-refractory essential tremor (ET). The Vim is not readily visualised on conventional MRI and targeting is routinely performed indirectly, with atlas co-ordinates. Inaccurate targeting due to interindividual anatomical variability can result in side effects and reduced efficacy. FAT1-weighted MRI is a high-resolution, high-fidelity modality that combines fractional anisotropy mapping and anatomical T1 sequences and allows direct visualisation of the Vim. Here, we assessed the outcomes of ET patients treated with a novel FAT1-weighted MRgFUS thalamotomy technique.

Methods

Targeting was performed through direc

SUBMITTER: Xu SS 

PROVIDER: S-EPMC12306238 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature