Associations of age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy with glycaemia and risk of dementia: a study based on the population-based UK Biobank cohort.

ABSTRACT:

Introduction

Menopausal factors, including age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy (HRT), have been associated with dementia risk, which might be due to increased glucose levels after menopause. This study investigated the associations of these menopausal factors with glycaemia and dementia risk, and whether glycaemia mediates the association of menopausal factors with dementia risk.

Methods

We used longitudinal data from the population-based UK Biobank cohort (n=147 119 women; mean±SD age 55.2±8.0 years at baseline). Menopausal status, bilateral oophorectomy, hysterectomy, HRT and age at natural menopause, surgery and HRT were self-reported. Glycaemia was measured with fasting plasma glucose and haemoglobin A1c (HbA1c) levels.

SUBMITTER: Geraets A 

PROVIDER: S-EPMC12306347 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature