Predictors and course of hypertension in Wilms tumour patients: a retrospective observational cohort study.

ABSTRACT:

Introduction

Wilms tumour is the second most common extracranial solid tumour in paediatric patients. It is frequently associated with hypertension due to renal artery compression and activation of the renin-angiotensin-aldosterone system. This study aimed to identify predictors of hypertension, assess therapeutic factors and evaluate its impact on renal function.

Methods

We retrospectively analysed 67 patients treated for Wilms tumour following International Society of Paediatric Oncology (SIOP) guidelines at our institution between 2005 and 2024. Clinical records, radiological reports and laboratory data were collected. Statistical analyses were performed to assess the relationship between hypertension, tumour characteristics, treatment and renal function.

Results

H

SUBMITTER: Braun Y 

PROVIDER: S-EPMC12306372 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature