Ultra-Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling.

ABSTRACT: 3D bioprinting bridges tissue engineering and additive manufacturing, however developing bioinks with balanced biological and physical properties remains a challenge. Hyaluronic acid (HA) is a promising base material due to its biocompatibility and cell-recognition features. An HA-based bioink is designed using dynamic disulfide-crosslinking at physiological pH by modifying HA with cysteine moieties. To overcome the slow gelation kinetics typical of disulfide-crosslinked hydrogels, potassium iodide (KI) is introduced, accelerating gelation in a concentration-dependent manner. KI not only enhances gelation but also provides radical scavenging properties while maintaining hydrogel integrity. A low KI concentration (50 mm) offers more than a 3 h printing window, ensures cell viability, and fa

SUBMITTER: Tavakoli S 

PROVIDER: S-EPMC12306391 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature