Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse-induced atrophy.

ABSTRACT: Reductions in skeletal muscle mitochondrial respiration or increases in mitochondrial reactive oxygen species (ROS) are often interpreted as 'mitochondrial dysfunctions'. However, such changes can also occur as intentional programmed responses to stressors. The term 'mitochondrial dysfunction' could therefore consider the net impact of such responses on other cellular functions. In the case of disuse-induced skeletal muscle atrophy, lower mitochondrial respiration, increased ROS and increased mitochondrial-linked apoptosis have been associated with muscle loss. Such observations support hypotheses that mitochondria contribute to atrophy. If true, there are exciting opportunities for exploring therapeutic strategies that prevent such changes in mitochondrial metabolism. These observations m

SUBMITTER: Delfinis LJ 

PROVIDER: S-EPMC12306405 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature