Curcumin-primed milk-derived extracellular vesicles remodel hair follicle microenvironment for the treatment of androgenetic alopecia.

ABSTRACT: Androgenetic alopecia (AGA) is a globally prevalent condition, with limited treatment options and significant adverse effects associated with existing therapies. The primary pathogenic mechanisms of AGA involve androgen-mediated regulatory pathways, molecular alterations affecting hair regeneration, and inflammation in the perifollicular microenvironment. In this study, we first investigated the topical application of testosterone with varied doses for AGA mouse model induction, in which the High-dose group exhibited the most robust model development and provided a more comprehensive set of criteria for successful AGA model establishment. Then, curcumin-primed milk-derived extracellular vesicles (Cur-mEVs) were fabricated for the therapy of AGA with the in-house developed mouse model descr

SUBMITTER: Hou C 

PROVIDER: S-EPMC12306444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature