The impact of anatomical recipient liver abnormalities on rat liver transplantation.

ABSTRACT:

Background

Orthotopic rat liver transplantation (OLT) is widely used in basic research; normal liver anatomy and structures are attributable to its success, but its deformities are complicated by a negative OLT.

Methods

For tolerance induction, we used OLT from Lewis to Brown Norway (BN) rats as a chronic rejection model and encountered two anatomical deformities in the recipient livers. The outcomes of OLT were analyzed.

Results

Of the 47 liver transplantations, the accessory liver lobe occurred in four cases, and bifurcations of liver outflow occurred in five cases in BN rats. For the accessory liver lobe, we discontinued OLT in one patient with a large accessory liver lobe. Two rats died from pneumothorax upon separation, and one case succeeded with a small lobe. F

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12306482 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature