Genetic markers involved in neuroinflammation in Down syndrome: a systematic review.

ABSTRACT: The immune system plays a fundamental role in protecting human body organs and tissues; however, when exacerbated, it can contribute to the pathology of various conditions. In the central nervous system, immune cell activation, or neuroinflammation, is a key factor in several neurodegenerative diseases. In Down syndrome (DS), the additional copy of chromosome 21 alters gene expression, potentially enhancing inflammatory processes such as neuroinflammation. Therefore, understanding the genetic factors influencing neuroinflammation in DS is essential for identifying biomarkers and therapeutic targets.

Objective

Identify genetic markers involved in neuroinflammatory processes in individuals with DS.

Methods

A comprehensive search was conducted in Medical Literature Analysis and

SUBMITTER: Silva MN 

PROVIDER: S-EPMC12306487 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature