Impact of Depressive Symptom Severity on Stroke Risk in a US Cohort of People with HIV.

ABSTRACT:

Background

Depression is a common psychiatric condition and an independent stroke risk factor among people with HIV (PWH). The impacts of depressive symptom severity on stroke are not clear in PWH.

Methods

We studied adult PWH in clinical care at 5 Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites with ≥1 assessment for depressive symptoms (Patient Health Questionnaire-9) from 2010 to 2022. We used Cox models to evaluate (1) associations between time-varying depressive symptom severity and adjudicated incident stroke, serially adjusted for clinical factors and (2) modification of this association by age and sex. Participants were followed from 6 months after first CNICS visit or date the CNICS site began stroke adjudication (baseline) (whichever

SUBMITTER: Ma J 

PROVIDER: S-EPMC12306592 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature