Genetic testing referral and germline pathogenic variants in patients with breast cancer and another non-breast cancer.

ABSTRACT:

Background

Guidelines recommend germline genetic testing for specific combinations of primary cancers and ages of diagnoses, but do not recommend testing for all patients with multiple primary cancers (MPC). Patients with breast cancer are more likely to receive genetic testing. Here, we evaluated whether a first breast cancer was more likely than another first cancer type to prompt testing referral.

Methods

Using Oncoshare, a breast cancer research database of medical records and the California Cancer Registry, we identified female patients with MPC diagnosed January 2000-June 2023 with breast cancer as either the first or second cancer and seen at Stanford Health Care. We analyzed genetic testing rates after first versus second cancer diagnosis and the yield of pathogenic

SUBMITTER: Hodan R 

PROVIDER: S-EPMC12306642 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature