Pathogenesis of Chapare virus in cynomolgus macaques.

ABSTRACT: Chapare virus (CHAPV) is an emerging New World arenavirus that is the causative agent of Chapare haemorrhagic fever (CHHF) responsible for recent outbreaks with alarmingly high case fatality rates in Bolivia near the Brazilian border. Here, we describe a nonhuman primate (NHP) model of CHHF infection which represents an essential tool to understand this emerging biological threat agent. Cynomolgus macaques challenged intravenously with CHAPV develop clinical disease, which recapitulates several key features of human CHHF. All subjects lost weight and had clinical scores following the CHAPV challenge. Notably, one of four NHPs developed a lethal disease with viral hepatitis and haemorrhagic features. Clinical chemistry and haematology revealed leukopoenia, anaemia, thrombocytopenia, and inc

SUBMITTER: Johnson DM 

PROVIDER: S-EPMC12306676 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature