How different cardioplegic solutions influence genes expression and cytokine response in an immature rat heart model of ischemia/reperfusion?

ABSTRACT:

Introduction

The use of cardioplegia not only achieves cardiac arrest but also minimizes ischemic/reperfusion (I/R) injury, potentially improving short- or long-term outcomes. The aim of this study was to evaluate the impact of different cardioplegic solutions - del Nido, Custodiol HTK and St. Thomas on genes expression and cytokines response in an immature rat heart model of I/R using the Langendorff preparation. Expression of genes which are involved in cell cycle, proliferation, apoptosis resistance and response to hypoxia were determined in cardiac tissue, as well as levels pro/anti-inflammatory cytokines were measured.

Methods

A total of 39 male Wistar albino rats were utilized in this study. Experimental animals were divided into 3 groups, four animals in each followin

SUBMITTER: Mamedov A 

PROVIDER: S-EPMC12306747 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature