Cost-effectiveness assessment of liquid biopsy for early detection of lung cancer in Brazil.

ABSTRACT:

Introduction

Lung cancer has a low survival rate due to late diagnosis, with most cases detected at advanced stages. Liquid biopsy, a non-invasive alternative to tissue biopsy, has emerged as a potential screening tool for early lung cancer detection. This study evaluates the cost-effectiveness of liquid biopsy screening using an autoantibody test (EarlyCDT-Lung®) in high-risk populations from the perspective of the Brazilian Unified Health System (SUS).

Methods

A decision-analytic model was developed, combining a decision tree and a Markov model to compare two strategies: standard clinical diagnosis without screening and liquid biopsy screening followed by confirmatory diagnostics. Model inputs included test accuracy, treatment costs, and survival data derived from systemat

SUBMITTER: Senna KM 

PROVIDER: S-EPMC12306772 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature