Age-dependent ACE2/TMPRSS2 expression and SARS-CoV-2 household transmission in Gran Canaria.

ABSTRACT:

Background

This study aimed to assess whether the expression of ACE2 and TMPRSS2 is associated with susceptibility to and severity of COVID-19 across age groups. We also evaluated the role of children in household transmission of SARS-CoV-2.

Methods

We conducted a cross-sectional observational study including 258 households in Gran Canaria between March 10 and June 2, 2020. A total of 650 individuals (including 89 children under 18 years of age) were evaluated using a combined serological testing strategy to confirm past SARS-CoV-2 infection. Gene expression of ACE2 and TMPRSS2 was quantified from saliva samples. Demographic, clinical, and household exposure data were collected for analysis.

Results

The combined serological approach increased diagnostic sensitivity by

SUBMITTER: Poch-Paez J 

PROVIDER: S-EPMC12306786 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature