Therapeutic peptides and their delivery using lipid-based nanoparticles.

ABSTRACT: Therapeutic peptides have become an intensively anticipated research field for novel drug discovery and design owing to their high specificity, efficacy, and biocompatibility. The advances in computer technology and structural biology, together with the invention of chemical peptide synthesis methods, have led to tremendous progress in this research field. Over the years, more than 100 peptide-based therapeutics have been approved for clinical use, and many others are currently under clinical trials. However, the in vivo application of therapeutic peptides is hindered by intrinsic disadvantages of peptides, such as poor stability against enzymatic degradations, short in vivo half-life, and low oral bioavailability. Therefore, strategies for efficiently protecting the peptides

SUBMITTER: Yen JH 

PROVIDER: S-EPMC12306875 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature