Associations of Plasma p-tau181 With Age, Adjusted for Kidney Function and Sociodemographic Factors.

ABSTRACT:

Introduction

Plasma phosphorylated tau (p-tau) levels, such as p-tau181, are elevated in Alzheimer's disease compared to cognitively unimpaired individuals. They represent potential candidate blood biomarkers for use in memory services where CSF examinations are not available. However, the effect of age on plasma p-tau levels remains undetermined. Limited studies have investigated the association between age and plasma p-tau thus far, and fewer still have differentiated levels by brain amyloid pathology. Characterising these associations and determining if this is influenced by sociodemographic factors or medical comorbidities is important for establishing blood biomarker reference ranges.

Methods

Using ADNI data, we analysed 860 observations (581 participants; age range: 55

SUBMITTER: Hazan J 

PROVIDER: S-EPMC12306926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature