Treatment Without Cost? Effects and Side Effects of an Internet-Based Intervention for Depression: Randomized Controlled Trial.

ABSTRACT:

Background

Internet-based interventions for depression are increasingly integrated into health care due to their effectiveness, availability, and cost-effectiveness. However, negative effects have largely been ignored.

Objective

This study aimed to evaluate both positive and negative effects of an unguided intervention.

Methods

In total, 303 participants were analyzed using mixed models for repeated measures to assess changes in depressive symptoms via Beck Depression Inventory-II (primary outcome) after 12 weeks compared to waitlist controls with care as usual. Secondary endpoints included depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]), self-esteem, and quality of life. Negative effects were evaluated using the positive and negative effects of psychothe

SUBMITTER: Baumeister A 

PROVIDER: S-EPMC12306951 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature