Decreased quantitative transport mapping velocity in the middle cerebral artery-supplied temporal lobe in Alzheimer's disease.

ABSTRACT:

Introduction

Reduced blood perfusion has been observed in patients with Alzheimer's disease (AD), but the patterns of blood perfusion changes during AD progression remain insufficiently explored.

Methods

Quantitative transport mapping (QTM) is a novel biophysical modeling-based method for quantifying blood perfusion velocity. In this study, we examined regional changes in perfusion velocity throughout AD progression by combining QTM velocity measurements with Granger causality analysis using cross-sectional data, as a secondary and exploratory analysis following our previous QTM work, aiming to offer a comprehensive view of the QTM velocity patterns based on the arterial territories.

Results

Reduced QTM velocity was observed in the middle cerebral artery (MCA)-supplie

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12307133 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature