Bioinformatics-based analysis of the relationship between STC1 expression and immune infiltration in gastric cancer.

ABSTRACT:

Objective

The study assessed the expression of STC1, and its potential as an immunotherapy target in gastric cancer (GC).

Methods

RNAseq data from the TCGA_STAD project and TCGA-GTEx project of UCSC XENA website and microarray data from GEO (GSE66229) were downloaded. Differential STC1 mRNA expression between GC and non-carcinoma tissues was examined. Its relation to clinicopathological characteristics and prognosis was evaluated using univariate and multivariate Cox regression. Tumor infiltrating immune cells (TIICs) in the tumor microenvironment (TME) were assessed by ssGSEA, and T-cell exhaustion by TIMER. Single-cell RNA sequencing (scRNA-seq) analysis was performed to validate the correlation between STC1 expression and T-cell exhaustion markers. Gene Set Enrichment Ana

SUBMITTER: Ma W 

PROVIDER: S-EPMC12307138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature