Systematic analysis of ZDHHC9 as a potential prognostic and immunotherapy biomarker in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) represents a highly heterogeneous malignancy and continues to be a leading source of death among women worldwide. Enhancing diagnostic and therapeutic approaches necessitates a thorough grasp of the underlying molecular pathways and the identification of dependable biomarkers. Although palmitoyl transferases, particularly ZDHHC9, have been associated with the progression of various cancers, their specific role in BC remains incompletely understood.

Methods

In this investigation, TCGA and GTEx databases were utilized to analyze the expression patterns of ZDHHC9 and to evaluate its prognostic significance. Moreover, the regulatory pathways involving ZDHHC9 were explored via co-expression analysis and differential gene enrichment studies. Insights

SUBMITTER: Zhou D 

PROVIDER: S-EPMC12307147 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature