Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a prevalent ocular condition associated with aging, serving as a significant contributor to vision loss among middle-aged and older individuals. Studies have shown that AMD and integrated stress response (ISR) are associated with oxidative stress, but no specific molecular mechanisms have been identified. Therefore, this study aimed to identify potential biomarkers for AMD through bioinformatics analysis based on the transcriptome database and integrated stress response related genes (ISR-RGs).

Methods

Transcriptomic data GSE76237, GSE247168, and ISR-RGs were sourced from public databases and related literature. The biomarkers associated with AMD were identified by differentially expressed gene (DEG) analysis, intersection

SUBMITTER: Niu J 

PROVIDER: S-EPMC12307159 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature