Oxidative balance score predicts chronic kidney disease risk in overweight adults: a NHANES-based machine learning study.

ABSTRACT:

Background

Oxidative stress plays a pivotal role in the pathogenesis of chronic kidney disease (CKD), particularly in overweight and obese populations where adipose tissue dysfunction exacerbates systemic inflammation and metabolic derangements. The oxidative balance score (OBS) is a composite index that integrates dietary antioxidants and pro-oxidant exposures, offering a quantifiable surrogate of oxidative burden. However, its utility in CKD prediction among overweight adults remains unclear.

Methods

We analyzed data from 28,377 overweight or obese participants in ten NHANES cycles (1999-2018). OBS was calculated based on 16 dietary components and 4 lifestyle factors. CKD was defined using KDIGO guidelines. Survey-weighted logistic regression models were used to assess the

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12307168 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature