Lactylation-related gene signatures identify glioma molecular subtypes with prognostic, immunological, and therapeutic implications.

ABSTRACT:

Introduction

Lactic acid is a by-product of energy metabolism and a signaling molecule that influences tumor progression by regulating immune cell function, angiogenesis, and epigenetic modifications.

Methods

This study analyzed data from the TCGA database on gliomas to systematically elucidate the expression patterns, prognostic value, and functional regulatory networks of lactylation-related genes.

Results

In this study, 17 lactylation-related prognostic genes were identified through the analysis of TCGA-GBM data. Using non- negative matrix factorization (NMF), two GBM subtypes based on lactylation- related genes (LRGs), termed GBM1 and GBM2, were identified. Survival analysis revealed that the overall survival (OS) of the GBM1 group was significantly lower than tha

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12307187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature