Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.

ABSTRACT: Phenotypic modification of dorsal root ganglion (DRG) neurons represents an important mechanism underlying neuropathic pain. However, the nerve injury-induced molecular changes are not fully identified. To determine the molecular alterations in a broader way, we have carried out cDNA array on the genes mainly made from the cDNA libraries of lumbar DRGs of normal rats and of rats 14 days after peripheral axotomy. Of the 7,523 examined genes and expressed sequence tags (ESTs), the expression of 122 genes and 51 expressed sequence tags is strongly changed. These genes encompass a large number of members of distinct families, including neuropeptides, receptors, ion channels, signal transduction molecules, synaptic vesicle proteins, and others. Of particular interest is the up-regulation of gam

SUBMITTER: Xiao HS 

PROVIDER: S-EPMC123072 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature