Exploring the synergistic effects of Life's Essential 8, insulin resistance, and CRP on cardiometabolic multimorbidity risk.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM) refers to the co-occurrence of two or more cardiometabolic diseases (CMDs), including coronary artery disease (CAD), stroke, and type 2 diabetes mellitus (T2DM), posing a substantial public health concern. Although Life's Essential 8 (LE8), a cardiovascular health (CVH) metric incorporating behavioural and metabolic factors, has been developed, its relationship with CMM remains unexplored. This study examines the independent and combined effects of LE8, insulin resistance (IR) and C-reactive protein (CRP) on CMM risk.

Methods

In this prospective cohort study, 304,568 UK Biobank participants without CMM at baseline were followed. The association between LE8 and CMM risk was assessed using Cox proportional hazards models, and dos

SUBMITTER: Liu J 

PROVIDER: S-EPMC12307207 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature