Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a highly aggressive and deadly malignancy. Early identification of prognostic risk factors is crucial for guiding clinical management and improving patient outcomes. Lactylation modification plays a pivotal role in tumorigenesis, yet the regulatory mechanisms and prognostic significance of lactylation-related genes in HCC remain insufficiently understood.

Methods

This study screened for prognostically significant lactylation modification-related genes based on their expression levels, integrated with DFS, PFS, and OS data. HCC patients were stratified into three distinct lactylation modification subtypes (C1, C2, C3) using the NMF algorithm. Differentially expressed genes across the three subtypes were identified through an inters

SUBMITTER: Wu LH 

PROVIDER: S-EPMC12307209 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature