DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.

ABSTRACT: CD4⁺ regulatory T (T_reg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue T_reg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human T_reg cells from skin and blood and integrated these data into a multiomic framework, including chromatin accessibility and gene expression. This analysis identified programs that governed the tissue adaptation of skin T_reg cells. We found that subfamilies of transposable elements represented a major constituent of the hypomethylated landscape in tissue T_reg cells. Based on T cell antigen receptor sequence and DNA hypomethylation homologies, our data i

SUBMITTER: Beumer N 

PROVIDER: S-EPMC12307226 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature