Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma.

ABSTRACT: As a co-receptor for vascular endothelial growth factor, neuropilin receptor type-1 (NRP-1) plays a crucial role in tumor angiogenesis, growth, and metastasis, and is regarded as a promising target for cancer molecular imaging and therapy. However, few data on inhibitory effect of an anti-NRP-1 monoclonal antibody on HCC with different NRP-1 expression levels have been reported. This study aimed to investigate inhibitory effect of an anti-NRP-1 monoclonal antibody (A6-11-26) on different types of HCC, with a view to further understanding the role of A6-11-26 in HCC. Three different types of HCC cell lines (Bel-7402, SMMC-7721 and HepG2) were conducted in this study. MTT, colony formation test, cell morphology, and flow cytometry were used to assess the inhibitory effect of A6-11-26 on thre

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12307266 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature