The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.

ABSTRACT:

Introduction

Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are among the most common forms of primary glomerular diseases, with a rising global incidence. Despite their clinical importance, the underlying pathogenesis of these diseases and the development of reliable non-invasive diagnostic tools remain inadequately understood. Accumulating evidence suggests that gut microbiota and its associated metabolites may play a crucial role in the development of kidney diseases via the gut-kidney axis. However, comprehensive studies integrating both microbiome and metabolomic data in IgAN and MN are still limited.

Methods

In this study, we performed integrated metagenomic sequencing and untargeted metabolomic profiling to investigate alterations in gut microbial

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12307357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature