Characteristics and prognosis of language impairment in subcortical aphasia of acute stroke patients.

ABSTRACT:

Background

Subcortical aphasia, caused by lesions in deep brain structures such as the basal ganglia, thalamus, and periventricular white matter, remains poorly understood due to its heterogeneous clinical presentations and disputed neural mechanisms. Unlike classical cortical aphasia syndromes, subcortical aphasia often involves subtle deficits in lexical, semantic, and phonological processing, which may be underestimated by standard assessments.

Objective

This study aimed to comprehensively characterize the language profiles of patients with subcortical aphasia using a multidimensional assessment approach, and to explore the underlying components of language impairment and their relationship to aphasia severity.

Methods

Thirty-four right-handed, native Chinese-speak

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC12307362 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature