Distinct cervical microbiome and metabolite profiles before and after menopause: implications for cervical cancer progression.

ABSTRACT:

Introduction

Cervical cancer is the fourth most common malignancy in women and is primarily caused by persistent infection with high-risk human papillomavirus (HPV). In addition, host immune responses, genetic factors, and lifestyle habits also have etiological roles. The cervicovaginal microbiome undergoes dynamic changes during menopause, which may be involved in the progression of cervical neoplasia. We aimed to elucidate the association between cervical microenvironmental changes and the progression of cervical neoplasia before and after menopause by integrating analyses of the cervical microbiome, related metabolites, cytokines, and microRNAs.

Methods

A total of 248 HPV-positive women with cervical neoplasia, including 17 with cervical intraepithelial neoplasia (CIN1),

SUBMITTER: Kawasaki R 

PROVIDER: S-EPMC12307382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature