Evaluation of non-motor symptoms in Parkinson's disease using multiparametric MRI with the multiplex sequence.

ABSTRACT:

Background

Non-motor symptoms (NMS) in Parkinson's disease (PD) often precede motor manifestations and are challenging to detect with conventional MRI. This study investigates the use of the Multi-Flip-Angle and Multi-Echo Gradient Echo Sequence (MULTIPLEX) in MRI to detect previously undetectable microstructural changes in brain tissue associated with NMS in PD.

Methods

A prospective study was conducted on 37 patients diagnosed with PD. Anxiety and depression levels were assessed using the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD), respectively. MRI techniques, including 3D T1-weighted imaging (3D T1WI) and MULTIPLEX - which encompasses T2*-mapping, T1-mapping, proton density-mapping, and quantitative susceptibility mapping (QSM)-were performed. Bra

SUBMITTER: Sui H 

PROVIDER: S-EPMC12307406 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature