Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice.

ABSTRACT:

Introduction

Breast cancer is the most frequently diagnosed cancer in women worldwide. Alcohol consumption is a significant and modifiable risk factor, yet the mechanisms linking alcohol to breast cancer progression remain unclear. Recent evidence suggests that the gut microbiome-a complex ecosystem that modulates metabolism, immunity, and inflammation-may act as a mediator of alcohol-induced tumor promotion. We hypothesized that binge-like alcohol exposure induces gut dysbiosis, which in turn drives systemic inflammation and carcinogenic processes.

Methods

We utilized MMTV-Wnt1 transgenic mice, a well-established model for mammary tumor development, along with wild-type FVB mice. Adolescent and adult female mice were administered binge-like doses of ethanol via intraperiton

SUBMITTER: Li H 

PROVIDER: S-EPMC12307441 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature