Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials.

ABSTRACT:

Background

Metabolic syndrome (MetS) is a prevalent metabolic disease that significantly increases the risk of type 2 diabetes, cardiovascular diseases, and overall mortality. Current medications have limited effects on the various components of MetS. Berberine has demonstrated unique comprehensive therapeutic benefits for MetS, but its efficacy remains uncertain.

Objective

To comprehensively evaluate the efficacy and safety of berberine on MetS indicators.

Methods

Our study provides a comprehensive evaluation of the efficacy and safety of berberine for MetS components through systematic review and meta-analysis, from the aspects of study characteristics, risk of bias, meta-analysis, sensitivity analysis, meta-regression, and publication bias.

Results

The resul

SUBMITTER: Liu D 

PROVIDER: S-EPMC12307485 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature