Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses.

ABSTRACT: Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that govern these responses are diverse due to the large number of activating and inhibitory NK receptors that modulate NK functions and the diversity of corresponding ligands that are differentially expressed in acute lymphoblastic and myeloblastic leukemias. We identified resting NKG2A⁺ NK cells and NKG2A⁺KIR⁺ NK cell subsets as the most effective in eliminating lymphoid and myeloid leukemic cells respectively. The NKG2A⁺KIR^±CD57^- cell subsets show high expression of activating receptors and a functional transcriptomic profile, but differ in KIR2DL5 expression. The frequency of KIR2DL5⁺ NK cells increa

SUBMITTER: Ferron E 

PROVIDER: S-EPMC12307528 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature