Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor.

ABSTRACT: Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related neuroinflammatory targets, and determine if the angiotensin receptor blockers (ARBs) candesartan can improve cognitive function in PND mouse models by modulating these targets. This study identified hypertension as a risk factor for cognitive dysfunction (OR = 1.0767, P = 0.0057) through Mendelian randomization (MR) analysis. Subsequently, bioinformatics techniques were employed to identify the neuroinflammatory targets associated with hypertension for ARBs. Differential analysis revealed Bdkrb1, Ccr1, and Thbs1 were PND biomarkers associated

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12307533 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature