CIAPIN1 promotes survival, proliferation, migration and glycolysis of endometrial cancer cells through PI3K/Akt pathway.

ABSTRACT: Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is a protein that regulates apoptosis and programmed cell death. This study aimed to assess the potential function of this molecule in curbing the proliferation, migration, and glycolysis of endometrial cancer cells and to elucidate its molecular mechanism. We obtained endometrial cancer tissue samples from our hospital to examine the CIAPIN1 expression levels. The human endometrial cancer cell line Ishikawa was transfected with CIAPIN1 siRNA. mRNA and protein expression were then measured using RT-qPCR and Western blotting techniques. CIAPIN1 expression was elevated in both endometrial cancer tissues and serum. CIAPIN1 overexpression enhances cell proliferation and migration, whereas CIAPIN1 silencing (siRNA) increases apoptosis. Mechanisti

SUBMITTER: Sun H 

PROVIDER: S-EPMC12307595 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature