Metabolomic profiling reveals unique markers for Pseudomonas aeruginosa LasR deficiency.

ABSTRACT: Pseudomonas aeruginosa is a primary driver of morbidity and mortality in cystic fibrosis (CF) patients. Throughout the course of infection, P. aeruginosa undergoes significant evolution and adaptation to the dynamic environment of the CF respiratory tract, leading to the emergence of diverse phenotypes. Among the variants that arise during this process are mutations in the regulatory gene lasR. While clinical significance of LasR deficiency is well recognized, current evidence does not fully elucidate the metabolic changes associated with the absence of this master regulator. To address this, we conducted untargeted metabolic profiling of cell supernatants (exometabolomes) to compare twenty-four P. aeruginosa strains, collected over 3-8 years from ten CF patients classified either as LasR

SUBMITTER: Garcia-Barcelo MT 

PROVIDER: S-EPMC12307636 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature