A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1.

ABSTRACT: Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. The present study was designed to identify and validate a previously unannotated protein encoded by circular RNA (circRNA), with the principal objective of elucidating its functional significance and mechanistic basis in gastric carcinogenesis.CircUBE2G1 (hsa_circ_003239) was identified as a translationally active circRNA exhibiting significant downregulation in gastric cancer. The novel protein product derived from circUBE2G1 translation, designated circUBE2G1-99aa, was confirmed through co-immunoprecipitation coupled with tandem mass spectrometry (LC-MS/MS), representing the f

SUBMITTER: Lu L 

PROVIDER: S-EPMC12307642 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature