Open-lung strategies and mechanical power during protective ventilation for laparoscopic anterior resection: a randomised controlled trial.

ABSTRACT: Higher intraoperative mechanical power (MP) is associated with increased postoperative pulmonary complications (PPCs). We hypothesised that periodic alveolar recruitment manoeuvres (PARM) alone, as an open-lung strategy for intraoperative protective ventilation, would reduce MP, thereby potentially mitigating PPCs. Seventy-five non-obese participants were equally allocated to either alveolar recruitment manoeuvres every 30 min alone (PARM group), or medium positive end-expiratory pressure (PEEP) of 6-8 cmH₂O alone (PEEP group), or a combination of medium PEEP and PARM (combination group). As a result, the median (interquartile range, IQR) MP in the PARM group was lower than in the other groups (PARM, 4.34 [3.58-5.27]; PEEP, 6.47 [5.83-7.74]; combination, 6.32 [5.16-7.36] J min

SUBMITTER: Guo J 

PROVIDER: S-EPMC12307646 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature